Dosage: The 5 mg dose is a common maintenance dose, typically reached after an initial 4-week starting dose of 2.5 mg to help minimize gastrointestinal side effects.
Mechanism of Action
Tirzepatide mimics the effects of the natural incretin hormones GIP and GLP-1. This dual action helps manage blood sugar and appetite in several ways:
Stimulates the pancreas to release more insulin when blood sugar levels are high.
Reduces the amount of sugar produced and released by the liver.
Slows down the emptying of the stomach, which helps a person feel full for longer, reduces food intake, and aids in weight loss.
Key Indications
Type 2 Diabetes: To improve glycemic control in adults, in combination with diet and exercise.
Weight Management: For chronic weight management in adults with obesity (BMI of 30 kg/m² or greater) or who are overweight (BMI of 27 kg/m² or greater) with at least one weight-related condition.
Obstructive Sleep Apnea: Approved as an adjunct to diet and exercise to treat moderate to severe obstructive sleep apnea in people with obesity.
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