Description
Testosterone cypionate is an ester of testosterone – the primary male sex hormone (androgen) in humans. In chemical terms, esters are organic (carbon-based) compounds derived from acids in which at least one -OH (hydroxyl) substituent is replaced by an -OR (alkoxy) substituent.
Esters are highly important in biology, often serving as lipids (fats). Per example, cholesterol is the most common steroid hormone (and technically a lipid) that serves as a precursor to many biologically important hormones, including testosterone, estrogen, cortisol, and progesterone. As such, it might help to think of testosterone cypionate as a modified form of the natural testosterone your body produces, containing an ester bond with cyclopentylpropionate at the carbon-17β position. The image below compares the structures of testosterone to testosterone cypionate.
This alteration to the chemical structure of testosterone turns it into a “prodrug,” meaning your body converts it into a biologically active form after you administer it. Even though testosterone cypionate is a synthetic androgenic anabolic steroid, it is still considered a natural hormone since your body metabolizes it into the bioidentical form of testosterone.
The use of testosterone esters – like testosterone cypionate – is advantageous in clinical applications for a variety of reasons, including:
• The effective half-life and duration of action of testosterone can be controlled
• It improves the bioavailability of testosterone
• The dosage is easier to manipulate
• The time between administrations is significantly increased
There are several other testosterone esters used in medicine for treating low T, such as testosterone undecanoate, testosterone propionate, and testosterone enanthate. Testosterone cypionate, however, is the most common ester used for testosterone replacement therapy (TRT) in the U.S and Canada.
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